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Pimozide tablets

What is this medicine?

PIMOZIDE (PI moe zide) helps to reduce the muscle and speech tics that are caused by Tourette's syndrome.

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not take with grapefruit juice. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be prescribed for children as young as 12 years of age for selected conditions, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • abnormal production of milk

  • breast enlargement in both males and females

  • breathing problems

  • confusion

  • difficulty moving, slow movements, tremor

  • fever or chills, sore throat

  • males: prolonged or painful erection

  • males: trouble getting or maintaining an erection

  • missed or irregular menstrual periods

  • problems with balance, talking, walking

  • restlessness, pacing, inability to keep still

  • seizures

  • signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast or irregular heartbeat; palpitations; feeling faint or lightheaded, falls; breathing problems

  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired

  • signs and symptoms of neuroleptic malignant syndrome such as confusion; fast or irregular heartbeat; high fever; increased sweating; stiff muscles

  • signs and symptoms of tardive dyskinesia such as uncontrollable head, mouth, neck, arm, or leg movements

  • sudden numbness or weakness of the face, arm or leg

  • suicidal thoughts or other mood changes

  • trouble swallowing

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • dizziness

  • drowsiness

  • dry mouth

  • headache

  • tiredness

  • weight loss or weight gain

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aprepitant

  • certain antibiotics like azithromycin, clarithromycin, dirithromycin, erythromycin, telithromycin

  • certain antiviral medicines for HIV or AIDS like indinavir, nelfinavir, ritonavir, saquinavir

  • certain medicines for ADHD like amphetamine, dexmethylphenidate, dextroamphetamine, methylphenidate

  • certain medicines for depression like citalopram, escitalopram, fluoxetine, paroxetine, sertraline, fluvoxamine, nefazodone, venlafaxine, tricyclic antidepressants

  • certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole

  • certain medicines for irregular heart beat like amiodarone, bepridil, dofetilide, encainide, flecainide, propafenone, quinidine, sotalol

  • cisapride

  • dronedarone

  • thioridazine

  • zileuton

  • ziprasidone

  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)

This medicine may also interact with the following medications:

  • alcohol

  • amphotericin B

  • certain medicines for anxiety or sleep

  • corticosteroids like prednisone, methylprednisolone

  • diuretics

  • grapefruit juice

  • herbal supplements like betel nut

  • laxatives and enemas

  • medicines for Parkinson's disease like levodopa

  • medicines for seizures

  • narcotic medicines for pain

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • dementia

  • diabetes or high blood sugar

  • glaucoma

  • head injury

  • heart disease

  • history of irregular heartbeat

  • kidney disease

  • liver disease

  • low blood counts, like low white cell, platelet, or red cell counts

  • low blood pressure

  • low magnesium level in the blood

  • low potassium level in the blood

  • pheochromocytoma (an adrenal gland tumor)

  • Parkinson's disease or other movement disorders

  • previous heart attack or stroke

  • prostate disease

  • seizures

  • suicidal thoughts, plans, or attempt by you or a family member

  • trouble passing urine

  • an unusual or allergic reaction to pimozide, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Do not stop taking this medicine suddenly. You may need to gradually reduce the dose. Only stop taking this medicine on advice of your doctor or health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can increase dizziness and drowsiness. Avoid alcoholic drinks.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2018 Elsevier
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