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Narcotic Cough/Cold Preparations Oral syrup

What is this medicine?

CODEINE; PROMETHAZINE (KOE deen; proe METH a zeen) is a cough suppressant and an antihistamine. It helps to stop or reduce coughing due to colds or allergies. This medicine will not treat an infection.

How should I use this medicine?

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take this medicine with food or milk if it upsets your stomach. Take your doses at regular times. Do not take more medicine than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply. This medicine is not approved for use in children less than 6 years old. Certain formulations of this medicine are also not approved for use in adolescents less than 16 years old.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • blurred vision

  • breathing problems

  • dark urine

  • feeling faint or lightheaded

  • hallucinations

  • irregular heartbeat

  • muscle twitches or tremors

  • seizures

  • trouble passing urine

  • unusual bleeding or bruising

  • unusually weak or tired

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • dry eyes

  • headache

  • stomach upset, nausea

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • disopyramide

  • risperidone

This medicine may also interact with the following medications:

  • alcohol

  • antihistamines for allergy, cough and cold

  • barbiturate medicines for inducing sleep or treating seizures

  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

  • muscle relaxants

  • narcotic medicines (opiates) for pain

  • some medicines for depression, anxiety, or other mental disturbances

  • sleeping pills or tranquilizers

  • tramadol

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children. This medicine can be abused. Keep your medicine in a safe place to protect it from theft. Do not share this medicine with anyone. Selling or giving away this medicine is dangerous and against the law.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light.

Throw away any unused medicine after the expiration date. Discard unused medicine and used packaging carefully. Pets and children can be harmed if they find used or lost packages.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • asthma

  • glaucoma

  • head injury

  • difficulty passing urine

  • other chronic illness

  • seizure disorder

  • sleep apnea

  • stomach ulcer

  • an allergic or unusual reaction to codeine, promethazine, phenothiazines, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

You may develop tolerance to this medicine if you take it for a long time. Tolerance means that you will get less cough relief with time. Tell your doctor or health care professional if your symptoms do not improve or if they get worse. If you have a high fever, skin rash, or headache, see your health care professional.

Do not suddenly stop taking your medicine because you may develop a severe reaction. Your body becomes used to the medicine. This does NOT mean you are addicted. Addiction is a behavior related to getting and using a drug for a non-medical reason. If your doctor wants you to stop the medicine, the dose will be slowly lowered over time to avoid any side effects.

If you are diabetic, check your blood sugar levels regularly.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

This medicine may cause dry eyes and blurred vision. If you wear contact lenses you may feel some discomfort. Lubricating drops may help. See your eye doctor if the problem does not go away or is severe.

This medicine will cause constipation. Try to have a bowel movement at least every 2 to 3 days. If you do not have a bowel movement for 3 days, call your doctor or health care professional.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Last Review Date: 8/28/2012
© 2000-2014 Krames StayWell, 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

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