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Tolvaptan tablets (hyponatremia)

What is this medicine?

TOLVAPTAN (tol VAP tan) is used to treat low levels of sodium in the blood.

How should I use this medicine?

Take this medicine by mouth with a glass of water. This medicine will be started in a hospital. You may need to continue this medicine at home. Follow the directions on the prescription label. Do not stop and re-start this medicine on your own. You may need to go back to a hospital to re-start this medicine. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • black or tarry stools

  • chest pain

  • confusion

  • fast, irregular heartbeat

  • mood changes

  • seizures

  • trouble speaking

  • uncontrollable body movements

  • unusually weak or tired

  • vomiting blood

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation

  • dry mouth

  • increased hunger or thirst

  • increased urination

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • certain antibiotics like chloramphenicol, clarithromycin, dalfopristin; quinupristin, telithromycin

  • certain antiviral medicines for HIV or AIDS like atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir

  • certain medicines for fungal infection like ketoconazole, itraconazole, posaconazole, voriconazole

  • conivaptan

  • grazoprevir

  • idelalisib

  • mifepristone

  • nefazodone

This medicine may also interact with the following medications:

  • aprepitant

  • certain antibiotics like erythromycin, rifampin, rifabutin, and rifapentine

  • certain medicines for blood pressure, heart disease, irregular heart beat

  • certain medicines for seizures like carbamazepine, phenobarbital, phenytoin

  • cyclosporine

  • desmopressin

  • diuretics

  • fluconazole

  • grapefruit juice

  • hypertonic saline

  • St. John's Wort

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • cannot feel if you are thirsty

  • dehydration

  • history of alcohol abuse problem

  • kidney disease

  • liver disease

  • malnutrition

  • an unusual or allergic reaction to tolvaptan, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

You may need blood work done while you are taking this medicine.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2018 Elsevier