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Ibuprofen Injection

What is this medicine?

IBUPROFEN (eye BYOO proe fen) is a non-steroidal anti-inflammatory drug, also known as an NSAID. It treats pain, inflammation, and swelling.

How should I use this medicine?

This drug is injected into a vein. It is given by a health care provider in a hospital or clinic setting.

A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time.

Talk to your health care provider about the use of this drug in children. While it may be prescribed for children as young as 6 months for selected conditions, precautions do apply.

Patients over 65 years of age may have a stronger reaction and need a smaller dose.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions (skin rash, itching or hives; swelling of the face, lips, or tongue)

  • aseptic meningitis (stiff neck; sensitivity to light; headache; drowsiness; fever; nausea, vomiting; rash)

  • bleeding (bloody or black, tarry stools; red or dark brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eyes, gums, or nose)

  • blurred vision OR changes in vision

  • heart attack (trouble breathing; pain or tightness in the chest, neck, back or arms; unusually weak or tired)

  • heart failure (trouble breathing; fast, irregular heartbeat; sudden weight gain; swelling of the ankles, feet, hands; unusually weak or tired)

  • high potassium levels (chest pain; fast, irregular heartbeat; muscle weakness)

  • increase in blood pressure

  • infection (fever, chills, cough, sore throat, pain or trouble passing urine)

  • kidney injury (trouble passing urine or change in the amount of urine)

  • liver injury (dark yellow or brown urine; general ill feeling or flu-like symptoms; loss of appetite, right upper belly pain; unusually weak or tired, yellowing of the eyes or skin)

  • low blood pressure (dizziness; feeling faint or lightheaded, falls; unusually weak or tired)

  • low red blood cell counts (trouble breathing; feeling faint; lightheaded, falls; unusually weak or tired)

  • redness, blistering, peeling, or loosening of the skin, including inside the mouth

  • stroke (changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm or leg; trouble walking; dizziness; loss of balance or coordination)

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • cough

  • diarrhea

  • dizziness

  • upset stomach

  • vomiting

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • cidofovir

  • ketorolac

  • methotrexate

This medicine may also interact with the following medications:

  • alcohol

  • aspirin

  • diuretics

  • lithium

  • other drugs for inflammation like prednisone

  • pemetrexed

  • warfarin

What if I miss a dose?

This does not apply. This drug is not for regular use.

Where should I keep my medicine?

This drug is given in a hospital or clinic. It will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bleeding disorder

  • coronary artery bypass graft (CABG) within the past 2 weeks

  • heart attack

  • heart disease

  • heart failure

  • high blood pressure

  • if you often drink alcohol

  • kidney disease

  • liver disease

  • lung or breathing disease (asthma)

  • lupus

  • receiving steroids like dexamethasone or prednisone

  • smoke tobacco cigarettes

  • stomach bleeding

  • stomach ulcers, other stomach or intestine problems

  • take drugs that treat or prevent blood clots

  • an unusual or allergic reaction to ibuprofen, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this drug.

Do not take other drugs that contain aspirin, ibuprofen, or naproxen with this drug. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many non-prescription drugs contain aspirin, ibuprofen, or naproxen. Always read labels carefully.

This drug can cause serious ulcers and bleeding in the stomach. It can happen with no warning. Smoking, drinking alcohol, older age, and poor health can also increase risks. Call your health care provider right away if you have stomach pain or blood in your vomit or stool.

This drug may cause serious skin reactions. They can happen weeks to months after starting the drug. Contact your health care provider right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. Or, you might notice a red rash with swelling of the face, lips or lymph nodes in your neck or under your arms.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand up or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2021 Elsevier