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Lepirudin Solution for injection

What is this medicine?

LEPIRUDIN is an anticoagulant. It is used in a hospital setting to help prevent blood clots.

How should I use this medicine?

This medicine is for injection or infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • feeling faint or lightheaded, falls

  • heavy menstrual bleeding

  • signs and symptoms of bleeding such as bloody or black, tarry stools; red or dark-brown urine; spitting up blood or brown material that looks like coffee grounds; red spots on the skin; unusual bruising or bleeding from the eye, gums, or nose

  • signs and symptoms of a blood clot such as breathing problems; changes in vision; chest pain; severe, sudden headache; pain, swelling, warmth in the leg; trouble speaking; sudden numbness or weakness of the face, arm or leg

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • irritation at site where injected

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aspirin and aspirin-like medicines

  • medicines that treat or prevent blood clots like warfarin or heparin

  • mifepristone

This medicine may also interact with the following medications:

  • abciximab

  • cilostazol

  • clopidogrel

  • dipyridamole

  • eptifibatide

  • lamifiban

  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen

  • ticlopidine

  • tirofiban

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • bleeding disorders or hemophilia

  • high blood pressure

  • infection of the heart valves

  • kidney disease

  • liver disease

  • lumbar puncture or spinal anesthesia

  • recent surgery or trauma

  • stomach or intestinal ulcers

  • weak or unstable blood vessels

  • an unusual or allergic reaction to lepirudin, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Your condition will be monitored carefully while you are receiving this medicine.

Avoid sports and activities that might cause injury while you are using this medicine. Severe falls or injuries can cause unseen bleeding. Be careful when using sharp tools or knives. Consider using an electric razor. Take special care brushing or flossing your teeth. Report any injuries, bruising, or red spots on the skin to your doctor or health care professional.

If you are going to have surgery, tell your doctor or health care professional that you have received this medicine.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Last Review Date: 4/9/2014
© 2000-2014 Krames StayWell, 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

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