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Progesterone Vaginal insert

What is this medicine?

PROGESTERONE (proe JES ter one) is a female hormone. This medicine is used to help women who are going through an assisted reproductive technology (ART) treatment program to become pregnant.

How should I use this medicine?

This medicine is for vaginal use only. Do not take by mouth. Follow the directions on the prescription label. Wash your hands before and after use. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • abnormal vaginal bleeding

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • loss of appetite

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusually weak or tired

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • back pain

  • depressed mood or mood swings

  • increased appetite

  • fluid retention and swelling

  • nausea, vomiting

  • stomach cramps or bloating

What may interact with this medicine?

  • carbamazepine

  • rifampin

Do not use any other vaginal products without asking your doctor or health care professional.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • blood vessel disease, blood clotting disorder, or suffered a stroke

  • breast, cervical or vaginal cancer

  • heart disease

  • kidney disease

  • liver disease

  • miscarriage or abortion

  • vaginal bleeding

  • an unusual or allergic reaction to progesterone, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor or health care professional for a regular check on your progress.

This medicine can cause swelling, tenderness, or bleeding of the gums. Be careful when brushing and flossing teeth. See your dentist regularly for routine dental care.

Online Medical Reviewer: Louise Akin, RN, BSN
Online Medical Reviewer: Daphne Pierce-Smith, RN, MSN, FNP, CCRC
Last Review Date: 12/16/2009
© 2000-2014 Krames StayWell, 780 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.

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