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Rocky Mountain Spotted Fever (Blood)

Does this test have other names?

RMSF, Rocky Mountain spotted fever antibodies

What is this test?

Rocky Mountain spotted fever serum is a blood test used to look for antibodies, or proteins, that the body makes to fight Rocky Mountain spotted fever (RMSF) infections. RMSF is a serious bacterial infection caused by a bite from an infected tick. In most people, antibodies can't be found until at least a week after infection.

A blood sample is taken about a week after symptoms appear and again 2 to 4 weeks later. 

Why do I need this test?

You may need this test if your healthcare provider wants to confirm a diagnosis of RMSF and to see how well treatment is working. Symptoms of RMSF include:

  • Fever

  • Rash. This can happen 2 to 5 days after the fever, but some people never have a rash.

  • Headache

  • Muscle pain

  • Nausea

  • Vomiting

  • Belly pain

What other tests might I have along with this test?

Your healthcare provider might order other blood tests. These might include a complete blood cell count (CBC) and a chemistry panel. A low platelet count, low sodium level, or higher liver enzymes could mean RMSF. If you have a skin rash, your healthcare provider may order a skin biopsy to look for bacterial infection in the cells that line your blood vessels. 

What do my test results mean?

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

If your first test results are negative, it's still possible you are infected. It's critical to start treatment right away, so your healthcare provider may suggest treatment even if your results are negative. He or she will have you repeat the test in a week or two.

Healthcare providers look for a rise in the antibodies. If the second test shows a significant rise in antibodies, it can confirm that you have RMSF.

The antibodies may stay at higher levels for months or even years after infection. 

How is this test done?

The test is done with a blood sample. A needle is used to draw blood from a vein in your arm or hand. 

Does this test pose any risks?

Having a blood test with a needle carries some risks. These include bleeding, infection, bruising, and feeling lightheaded. When the needle pricks your arm or hand, you may feel a slight sting or pain. Afterward, the site may be sore. 

What might affect my test results?

Antigens may be present in your blood if you have been exposed to related organisms. Antibiotic treatment also can affect your test results.

How do I get ready for this test?

You don't need to prepare for this test. Be sure your healthcare provider knows about all medicines, herbs, vitamins, and supplements you are taking. This includes medicines that don't need a prescription and any illicit drugs you may use. 

Online Medical Reviewer: Freeborn, Donna, PhD, CNM, FNP
Online Medical Reviewer: Haldeman-Englert, Chad, MD
Date Last Reviewed: 11/1/2017
© 2000-2018 The StayWell Company, LLC. 800 Township Line Road, Yardley, PA 19067. All rights reserved. This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.